What is pqq supplement

Last updated: April 1, 2026

Quick Answer: PQQ (pyrroloquinoline quinone) is a naturally occurring compound found in fermented foods and vegetables, available as a dietary supplement for potential antioxidant and cellular energy support.

Key Facts

What is PQQ?

PQQ (pyrroloquinoline quinone) is a water-soluble compound classified as a redox cofactor and antioxidant. It was first identified in bacteria but has since been found in mammalian tissues and various food sources. Unlike traditional vitamins, PQQ functions through unique biochemical pathways that support cellular health.

Natural Sources of PQQ

PQQ occurs naturally in several foods including fermented beverages like noni juice, kiwifruit, peppers, celery, and fermented foods such as sake and soy sauce. The amounts found in food are typically small, which is why supplementation is sought by those interested in obtaining higher doses. Organic foods may contain higher PQQ levels than conventionally grown produce.

How PQQ Works

PQQ works primarily by promoting mitochondrial health, which are the energy-producing components of cells. It supports the production of ATP, the molecule responsible for cellular energy. Additionally, PQQ exhibits strong antioxidant properties, helping protect cells from oxidative stress and free radical damage. It may also support the formation of new mitochondria through mitochondrial biogenesis.

Potential Health Benefits

Research suggests PQQ supplementation may provide several benefits:

Supplementation and Safety

Most PQQ supplements contain 10-20 mg per serving, which aligns with dosages used in clinical research. PQQ is generally well-tolerated with few side effects reported. However, human clinical studies remain limited compared to animal research, so more evidence is needed to fully establish all health claims. Pregnant women, nursing mothers, and individuals on specific medications should consult healthcare providers before supplementing.

Related Questions

What foods contain PQQ naturally?

PQQ is found in noni juice, kiwifruit, peppers, parsley, celery, and fermented foods like sake and tempeh. The concentration in foods is typically small, usually measured in micrograms.

Does PQQ supplementation improve energy levels?

Studies suggest PQQ may support mitochondrial function and ATP production, potentially improving cellular energy. However, individual results vary and more human clinical trials are needed to confirm efficacy.

Are there any side effects of PQQ supplements?

PQQ is generally considered safe with minimal reported side effects in research. Some people report mild digestive effects. Always consult a healthcare provider before starting new supplements, especially if taking medications.

Sources

  1. PQQ and Health Benefits - NIH/PubMed CentralPublic Domain
  2. Pyrroloquinoline Quinone - WikipediaCC-BY-SA-3.0