What is vyvanse made of
Last updated: April 1, 2026
Key Facts
- Vyvanse's active ingredient is lisdexamfetamine dimesylate, a salt form of the amphetamine compound
- It contains inactive ingredients including microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and FD&C colorants
- Lisdexamfetamine is a prodrug that requires enzymatic conversion in red blood cells to become active dextroamphetamine
- The medication is available in capsule form with dosages ranging from 10mg to 70mg
- Vyvanse was developed by Naurex and first approved by the FDA in 2007 for ADHD treatment
Active Ingredient
Vyvanse contains lisdexamfetamine dimesylate as its active pharmaceutical ingredient. This compound is unique because it's a prodrug, meaning it's inactive until converted in the body. The body's red blood cells naturally metabolize lisdexamfetamine into dextroamphetamine, which is responsible for the medication's therapeutic effects.
Inactive Ingredients
Beyond the active ingredient, Vyvanse capsules contain several inactive ingredients that provide structure and stability:
- Microcrystalline cellulose (provides bulk)
- Croscarmellose sodium (aids dissolution)
- Magnesium stearate (lubricant)
- FD&C Blue No. 2 and other colorants (for capsule appearance)
- Gelatin (capsule material)
How Vyvanse Works
Unlike other ADHD medications that are immediately active, Vyvanse works through a unique mechanism. When taken orally, lisdexamfetamine passes through the gastrointestinal system and enters the bloodstream. Red blood cells contain the enzyme necessary to convert lisdexamfetamine to dextroamphetamine, which then produces the medication's therapeutic effects. This conversion process generally takes 1-2 hours, creating a slower onset of action compared to immediate-release amphetamines.
Clinical Uses
Vyvanse is FDA-approved for two primary conditions: ADHD in children and adults, and moderate to severe binge eating disorder. The medication helps increase dopamine and norepinephrine levels in the brain, improving focus, attention, and impulse control in ADHD patients. For binge eating disorder, it reduces the frequency of binge eating episodes.
Dosage Forms
Vyvanse comes exclusively in capsule form with doses ranging from 10mg to 70mg. Each capsule contains the specified amount of lisdexamfetamine dimesylate along with the inactive ingredients. The capsules are typically taken once daily in the morning.
Related Questions
Is Vyvanse a controlled substance?
Yes, Vyvanse is a Schedule II controlled substance because it contains amphetamine. It carries a high potential for abuse and dependence, requiring a prescription and careful monitoring.
How long does Vyvanse take to work?
Vyvanse typically begins working within 1-2 hours of taking it, as the body needs time to convert lisdexamfetamine to its active form. Peak effects occur around 3-4 hours after ingestion.
What are common side effects of Vyvanse?
Common side effects include decreased appetite, insomnia, increased heart rate, and dry mouth. More serious side effects can include chest pain and psychiatric symptoms, requiring medical attention.
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Sources
- FDA - Drug Information Public Domain
- Wikipedia - Lisdexamfetamine CC-BY-SA-4.0
- MedlinePlus - Medicine Information Public Domain