What causes hfmd

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Last updated: April 4, 2026

Quick Answer: Hand, Foot, and Mouth Disease (HFMD) is primarily caused by a group of viruses called enteroviruses, most commonly coxsackievirus A16 and enterovirus 71. These viruses spread easily through direct contact with an infected person's saliva, nasal secretions, blister fluid, or stool.

Key Facts

What is Hand, Foot, and Mouth Disease (HFMD)?

Hand, Foot, and Mouth Disease (HFMD) is a common viral illness that typically affects infants and children under the age of 10. While it can occur in adults, it is usually milder. HFMD is characterized by fever, sore throat, and the development of a rash or blisters on the hands, feet, and in the mouth. It is a contagious disease that spreads easily from person to person, making it a common concern in childcare settings and schools.

What Causes HFMD?

The primary culprits behind Hand, Foot, and Mouth Disease are viruses belonging to the enterovirus genus. The most frequent causes are:

These viruses are highly contagious and spread through several routes:

The viruses that cause HFMD are more prevalent during warmer months, typically the summer and early fall, though outbreaks can occur at any time of the year.

How Does HFMD Spread?

Understanding the transmission of HFMD is key to prevention. The viruses are shed in the saliva, nasal secretions, blister fluid, and feces of infected individuals. This means that casual contact can be enough to spread the illness. For instance, a child might get HFMD by:

Because children are more likely to put their hands in their mouths and have close contact with others in group settings like daycare and schools, they are particularly susceptible to HFMD. Adults can get HFMD too, but it's less common and often less severe. People with weakened immune systems may be at higher risk for more severe disease.

Symptoms of HFMD

The symptoms of HFMD typically appear 3 to 6 days after exposure to the virus (this is the incubation period). The illness usually starts with:

A few days after the fever begins, sores may develop. These sores often start as small red spots, which then blister and can become painful. They are typically located on the tongue, gums, inside of the cheeks, and sometimes on the roof of the mouth. In addition to the mouth sores, a rash typically appears on the palms of the hands and the soles of the feet. This rash can also sometimes be found on the buttocks, knees, elbows, or genital area. The rash usually consists of flat red spots, but it can also develop into blisters. It is generally not itchy, although some people may experience mild itching.

When is Someone Contagious?

A person with HFMD is most contagious during the first week of their illness. However, the virus can still be present in their body and potentially spread for several weeks, even after symptoms have disappeared. This is why diligent hygiene practices are essential for preventing further transmission.

Prevention and Treatment

There is no specific antiviral medicine to treat HFMD. Treatment focuses on relieving symptoms. This includes:

Preventing the spread of HFMD relies heavily on good hygiene:

Keeping children home from school or daycare until their fever is gone and their sores have healed is also important to prevent outbreaks.

Sources

  1. Hand, Foot, and Mouth Disease | CDCfair-use
  2. Hand, foot, and mouth disease - Symptoms and causes - Mayo Clinicfair-use
  3. Hand, foot, and mouth disease - WikipediaCC-BY-SA-4.0

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